Mast cell activation - You are the healer (2023)

Mast cells produce many signaling molecules.

Mast cells help control immune system responses and help repair tissues. As part of the immune system's response to a variety of threats, such as infections and toxins, they release various signaling chemicals, also called mast cell mediators, into the body. They also release chemicals needed for other types of physical activity. These chemicals include inflammatory mediators such as lysosomal enzymes, biogenic amines (e.g. histamine and serotonin), heparin, cytokines (e.g. tumor necrosis factor), chemokines, prostanoids, leukotrienes and proteases, and chemicals involved in things like remodeling of bone growth, including growth factors and chondroitin sulfate. You release a lot of these chemicals during certain immune responses and allergic reactions. These chemicals have effects that include innate and adaptive immune responses, blood vessel dilation and new blood vessel formation, and detoxification of toxins. While they are a necessary part of bodily function, they are also responsible for promoting inflammatory and allergic responses during this process, especially when overstimulated or in excessive amounts.

Histamine is the signaling molecule we'll be looking at today. It should be taken into account that it is not the only signaling molecule released by mast cells. However, it is one that is released in large amounts, and when at very high levels, it can cause a bewildering array of symptoms that can be confusing as they come and go. Symptoms tend to wax and wane like the moon. Often a person will repeatedly encounter what they believe is the cause, only to decide it is something else. Changing symptoms also make it difficult for doctors to figure out what's going on.

Histamine isn't just bad, it's needed as a neurotransmitter and helps produce stomach acid, keeps you awake, keeps your bowels moving, and is important for your immune system when not in excess. So deregulation is the problem. Histamine itself is not bad. I would also venture to guess that while we believe that many of the responses are related to histamine, many of the other substances released by mast cells also produce some of the symptoms that we believe are largely related to histamine.

Mast cell activation and high histamine

Many symptoms are caused by mast cell activation, but the most common is a reaction to a food or drink within 15 minutes of consumption. If immediately after eating or drinking, the person's skin becomes red and sweaty, heart races, itching, hives appear on the skin, feeling anxious, abdominal pain and diarrhea, then you should see your doctor Mast cell activation disorder to be aware. Mast cells release 200 or more chemicals that can cause reactions. It is important to realize that this may have nothing to do with mast cell activation and may be entirely due to high levels of histamine or other biogenic amines in the food consumed.

Although many of these reactions are acute and rapid, histamine is also implicated in delayed hypersensitivity reactions. The response may depend on a number of factors, including the route of exposure (local or systemic), the sites of exposure (inhalatory or dermal), the dose of the allergen/toxin, and the level of prior sensitization to the allergen/toxin. Chronic histamine reactions can also be triggered by continued ingestion of moderate levels of histamine in food, just as an acute reaction can be triggered by a meal with very high levels of histamine in food.

Mast cell activation always causes high histamine levels, but histamine can be elevated without mast cell activation.

(Video) Top 7 Mast Cell Activation Syndrome Triggers You Should Avoid

Many of the following symptoms are due to high histamine and may be due to factors other than mast cell activation as explained below.

I would also add that histamine is a biogenic amine. there are othersbiogen aminathis can cause similar issues.

Furthermore, it is not just mast cells that produce histamine in the body. Histamine is synthesized by mast cells, basophils, platelets, histaminergic neurons, and enterochromaffin cells, where it is stored intracellularly in vesicles and released upon stimulation.


Symptoms usually come on quickly and are largely histamine related. Remember this.


  • Itchy skin with or without a rash
  • skin swelling
  • Slight flushing or redness of the skin
  • red rashes
  • Red bumps on the surface of the skin that itch
  • color loss
  • lichen planus
  • tenderness, pain
  • Dermatographism: Skin writing where you blush easily or have raised, honeycomb-shaped skin with a slight scratch on the skin.
  • urticaria
  • Overreaction to bee stings, mosquito bites, and many medications
  • Keloids have been found to have elevated levels of mast cells and histamine and heparin are thought to be involved.
  • hot flashes

Head, Brain, Mind and Nervous System

  • bad memory
  • bad concentration
  • difficulty finding words
  • Brain fog or disorientation after exposure to an allergen or toxin
  • Increased sensitivity to light, sound, noise, heat, cold, vibration.
  • dizziness
  • Headaches, migraines, cluster headaches, seizures, tremors, tics, paresthesias, dysautonomia (uncontrollable twisting movements)
  • Anxiety, panic attacks, mood swings, depression, obsessive-compulsive disorder, attention deficit hyperactivity disorder, behavior problems, temper tantrums
  • Increased chemical sensitivity and EMF sensitivity
  • general cognitive dysfunction
  • thermal dysregulation
  • reduced engine control
  • Insomnia, waking up early
  • ringing in the ears
  • Numbness, pain or tingling, especially in the hands and feet.
  • tics, tremors

eyes, ears, nose, throat and lungs

  • You cannot breathe fully, which leads to a lack of oxygen and many other problems.
  • anaphylaxis
  • Swelling of the eyes or throat after contact with a suspected allergen
  • mucus production
  • Wheezing or shortness of breath after exposure to an allergen or toxin
  • exercise-induced asthma
  • Ears itch and/or become blocked, ringing in the ears
  • Ringing in the ears, especially after consuming certain foods/drinks.
  • Watery eyes, eyes may feel gritty, burning, dryness, blurred vision and eyelid twitching or twitching, swollen, red and itchy eyes, conjunctivitis
  • Post nasal drip, nasal congestion, rhinitis (swollen nose), sinusitis (swollen sinuses)
  • nosebleeds
  • Sore throat, hoarseness, swollen throat
  • Swollen tongue or mouth sores, burning tongue or mouth, burning lips, lip sores, itchy throat, difficulty swallowing
  • Odors disturb the individual.
  • Dental problems - teeth are decaying

Heart and blood vessels - cardiovascular system

  • Chest pain
  • Palpitations, rapid pulse, especially after a meal such as peanuts, dairy, wheat, corn, soy or other foods
  • Low blood pressure and fainting, dizziness, lightheadedness, dizziness and fainting, palpitations, arrhythmias, chest pain, edema, postural orthostatic tachycardia syndrome, but can also cause hypertension
  • Blood pressure varies greatly

gastrointestinal tract

  • Gastrointestinal inflammation causing symptoms such as swollen tongue, bloating, nausea, vomiting, diarrhea and abdominal cramps.
  • Sudden swelling that makes the person look pregnant.
  • Sudden diarrhea with or without alternating constipation
  • Tingling or burning in the mouth or intestines.
  • Gastroesophageal Reflux Disease (GERD)
  • Food sensitivities/allergies along with chemical and drug sensitivities: worse with genetic variants of the detoxification system or overuse of the detoxification system
  • Dysbiosis or imbalance of intestinal flora
  • Impaired intestinal wall barrier - (leaky gut)


  • interstitial cystitis
  • recurrent urinary infections
  • frequent urination
  • cystitis sensation
  • pain when urinating
  • Urgency to urinate or loss of control

skeletal muscle

(Video) Diagnosing and Treating Mast Cell Activation Syndrome (MCAS)

  • fibromyalgia
  • muscle pain that moves
  • Joint pain that moves
  • Osteoporosis, bone loss

Problems related to menstruation

  • PMS - very bad symptoms
  • menstrual cramps
  • pain in the pelvic region
  • Pain or swelling in the genital area
  • endometriosis
  • hot flashes
  • decreased libido
  • heavy periods
  • sterility
  • Better During Pregnancy - Many symptoms disappeared from high DAO in pregnancy

Other common symptoms

  • Fatigue and malaise (being sick or feeling unwell)
  • feeling bloated or having many inflammatory conditions
  • enlarged lymph nodes
  • Excessive reactions to insect bites, iodinated contrast media, local and general anesthesia.
  • migratory angioedema (swelling) - accumulation of fluid around the eyes, lips, hands, feet.
  • Inflammation in the bladder, vagina, prostate, pelvic pain
  • Fibromyalgia-like pain that moves and is not easy to resolve
  • Symptoms come and go and I can't understand them
  • weight gain or loss
  • Intolerance to heat and cold.
  • Family history of cancer, particularly colon or bone marrow cancer

If the symptoms appear to be related to eating or drinking and occur quickly afterwards, it could be mast cell activation. Any symptoms that develop within minutes of putting a substance in your mouth should make you wonder if it's a mast cell reaction.

Involved in a variety of diseases.

  • Allergy - hay fever, implicated in some food allergies
  • asma
  • autism
  • Autoimmune diseases such as rheumatoid arthritis and lupus
  • anaphylaxis
  • Cancer - Links to some types of cancer
  • cardiovascular disease
  • CIRS - due to water damaged buildings
  • Connective tissue disease: May be a link between Ehlers-Danlos syndrome and autonomic dysfunction (dysautonomia).
  • Depression: mast cells related to depression and encephalitis
  • Diabetes
  • endometriosis
  • chronic fatigue
  • Chronic Inflammatory Response Syndrome
  • fibromyalgia
  • Gastrointestinal disorders such as GERD (reflux) and irritable bowel syndrome
  • headache
  • Many types of neoplasms
  • migraine
  • multiple chemical sensitivity
  • Multiple sclerosis
  • obesity
  • postural orthostatic hypotonia
  • Skin conditions like eczema and psoriasis.
  • tinnitus - ringing in the ears

How mast cells are activated

Mast cells have IgE receptors. Therefore, high IgE will stimulate mast cells to release their inflammatory mediators. Elevated IgE levels are found in atopic dermatitis, atopic asthma, allergic bronchopulmonary aspergillosis (unlike other diseases with elevated IgE, IgE levels can be used to monitor disease activity and response to therapy), allergic rhinitis perennial and seasonal allergic rhinitis (maximum values). observed 4 to 6 weeks after the peak of the pollen season), parasitic infections, some other types of viral or bacterial diseases and some types of cancer, in smokers and is a linkfor more details on IgE, mast cells and related diseases.

Mast cells can be stimulated by a variety of known and unknown stresses in the body. The mast cell senses a threat and is activated, producing chemicals that help the body deal with the threat. If it works correctly, everything is fine. However, when there are excessive threats, or the body reacts to something like a threat that is not a threat (allergens or sensitivities), or perhaps the mast cells are overzealous, we can get an abnormal response and excess chemicals are released. This sets off an alarm that starts an inflammatory cascade that affects both the innate and adaptive immune systems and a lot of inflammation. You may have seen someone react to a bee sting with swelling and difficulty breathing, or unusually severe inflammation from a mosquito bite. This is an abnormal activation of mast cells. This is not a common reaction. Mast cells overreacted. In an acute situation, this can even be fatal.

  • Mast cells can be activated by pathogens (viruses, bacteria, parasites), drugs, chemicals, food, infections, heavy metals and biotoxins such as poisons or mycotoxins and other toxins in general.
  • Common activators would be lipopolysaccharides and gliadin.
  • Mast cell activation has been shown to occur during T-2 mycotoxin poisoning, and clinically it appears that other mycotoxins also cause mast cell activation. Research studies indicate that fungi and yeast can trigger mast cell activation and antibodies to mycotoxins stimulate mast cells.
  • Mast cells have estrogen receptor sites and therefore can be stimulated by estrogen. It also reduces DAO levels. Progesterone naturally lowers histamine levels, so estrogen-dominant women have higher histamine levels.
  • Emotional stress can trigger mast cells.
  • Sometimes they mix and release mediators due to abnormal body signals.
  • Sometimes there are mast cell mutations that overproduce and spontaneously release mediators. These abnormal cells can grow out of control and are very sensitive to activation. This is a condition called mastocytosis.
  • Sometimes mast cells fire for no apparent reason. This is called idiopathic mast cell activation syndrome (MCAS).
  • Mast cell activation and degranulation involves the release of mediators such as histamine, serotonin, eicosanoids such as thromboxanes, leukotrienes and prostaglandins, and inflammatory cytokines such as TNF-alpha, chemokines and IL-4. In addition, mast cells store and release ATP in the extracellular environment. The result is an inflammatory response that can have a variety of systemic and localized effects.
  • When there are a large number of toxins or pathogens in the body and the body is overloaded, this causes the mast cells to become overstimulated and hypersensitive. Now, any stimulus, even the smallest one, can cause mast cells to respond and release their chemical packages, most importantly histamine. This type of reaction is often seen in people with mold disease or the Lyme disease co-infection called Bartonella, but it can also result from any type of environmental toxin or pathogenic toxin overload that irritates and inflames the body. We call this reaction "disorder of mast cell activation".

These triggers are due to certain allergens, toxins, pathogens or other stimuli that cause histamine-containing cells (mainly mast cells) to release their contents. Other triggers can be various activities in the body such as neuropeptides, complement factors (i.e. C3a and C5a), cytokines, hyperosmolarity, lipoproteins, adenosine, superoxidases, hypoxia (low oxygen), chemical and physical factors (extreme temperatures, trauma) . ), as well as medicines and food.

Other reasons for high histamine

While mast cell activation is one way to increase histamine, histamine can also increase in the body due to other triggers.

  • Genetic variants in genes that express enzymes that break down histamine can increase histamine due to lack of transformation and elimination.
  • Some intestinal bacteria also produce histamine, and both commensal and pathogenic bacteria belong to this group.
  • There are also foods rich in histamine. This includes fermented foods, aged cheeses, spoiled foods, salami, any rancid meat should be suspected.
  • Some foods can release histamine. (not the same for everyone, but some are more likely)
  • Anything that reduces DAO increases histamine.
    • Inflammatory or degenerative bowel disease is one of the causes of transient DAO deficiency.
    • Anything that disturbs the intestinal epithelium can lead to DAO deficiency, as the intestinal epithelium produces 90% DAO.
    • Some drugs inhibit DAO.
    • Genetic variant mentioned above.

Therefore, histamine comes from areas other than mast cells, and mast cell activation is not required for chronic histamine responses.

To diagnose

Diagnose mast cell activation or high histamine issues

Mast cell activation can look like many different diseases, and although there is evidence, it has limiting factors that prevent it from being as useful as one would like. This is often diagnosed by ruling out other possible diseases until only mast cell activation remains.

lab tests
  • Elevated Serum Mast Cell Tryptase: If tryptase is not elevated, it is not known whether a person's disease is only mast cell or primarily mast cell disease. It should be done within 4 hours or less of a mast cell syndrome flare and then collected again 24-48 hours after the initial test for comparison with the flare test.
  • Urinary levels of N-methylhistamine, prostaglandin 11B F2alpha, and/or leukotriene E4 are the tests used to diagnose MCAS.
  • Serum mast cell total tryptase should be collected 30 minutes to 2 hours after the onset of an episode, with baseline taken several days later. Urine testing is done using a 24-hour urine collection that begins immediately.
  • The problem with testing for chemicals released by mast cells is that they disappear extremely quickly, and unless you test in the middle of an episode, chances are the test will come back negative.
  • He may also perform IgE and IgE (anti-IgE, IgG) receptor testing to rule out activation of mast cells treated with autoantibodies.
  • Test for patients genetically negative for KIT-D816V to rule out the rare condition known as mastocytosis. Mastocytosis is different from the mast cell activation discussed here.
  • Also rule out genetic variants that may decrease the amount of DAO (diamine oxidase) available. The gene associated with DAO is AOC1. DNA variants are 47 C>T (rs10156191), 995 C>T (rs1049742), 1990 C>G (rs1049793).
  • The most abnormal biomarkers include MMP-9, C4a, TGF beta and VEGF.
Most useful lab test

Exame de urine para prostaglandina D2, DM, F2alfa e leucotrieno C4 ou N-metil-histaminacan be performed on random urine samples. They are a readily available non-invasive method to confirm chronic and episodic release of mast cell mediators. I'm not sure how many labs offer this these days, but it seems like the best way to test it out.

(Video) How To Treat MCAS Naturally | Healing Mast Cell Activation Syndrome

What to do about mast cell activation or high histamine levels?

The best thing to do when a person has a mast cell activation disorder is to find out what triggers it. Look for environmental toxins or pathogens in the person. Then remove the toxins/pathogens or remove the individual from the environment. This should stop mast cell activation. In the meantime, while you work this out and treat the problem, there are many things you can do to make the person feel better.The same treatments can be used for high histamine levels due to other factors.

  • If the person has a genetic variant associated with reduced diamine oxidase activity, I suggest using DAO meal replacements. If they have dysbiosis, and especially if tests show bacteria that tend to be associated with elevated histamine levels, a DAO replacement is a good idea. In addition, the use of intestinal flora, which tends to be associated with low histamine levels, can be used as a support. A company called Seeking Health makes both products. The DAO substitute is called Histamine Block and the intestinal flora is called Probiota Histaminx. No, I am not affiliated with the company. If a person is a sub-methylator, they will have issues with the other HNMT enzyme and will need to ensure methylation support.
  • Beware of probiotics. Some of them actually increase histamine. This is one of the reasons why some people feel that they cannot use probiotics and react to some fermented foods. They use products that contain an intestinal flora that increases histamine in the intestine. The Histaminx Probiota I mentioned has only one flora known to lower histamine in the gut.
  • Treat all infections
  • Treat leaky gut and support a healthy digestive tract
  • Eliminate sources of allergens
  • Stabilize mast cell release - see ideas below
  • You can limit histamine in your diet, but eliminating all histamine-containing foods can be quite a challenge for people. Many healthy foods contain histamine. A person may need to do this in the short term, but in the long term you want to eliminate causative factors and if there are genetic variants you want to support the person with methylation, DAO or otherwise as needed.
  • Minimize sources of emotional and mental stress as much as possible, as by reducing mast cell activation, stress can also increase histamine and other inflammatory mediators.
  • Use stress reduction techniques.
  • Stay away from chemicals and environmental toxins. This includes chemicals/preservatives/food coloring in your food.
  • Stay away from insects that sting or bite, as they also induce histamine.
  • Extreme temperatures, both hot and cold, can trigger histamine release.
  • There are drugs that block DAO or may contain histamine. Stay away from them. Some antihistamines are thought to do this and be careful if you stop them as if not reduced they can have a huge rebound effect.
  • Stay away from fragrances that bother you.
  • Anesthetics can increase histamine, so keep that in mind if you're having surgery.

histamine and food

One should be suspicious of any food considered to be high in histamine, as it can add fuel to the fire going on in your body. You're sensitive to the histamine released by your immune system, and histamine-rich foods will upset you if you're lacking in one or both of the enzymes that remove histamine (usually diamine oxidase, or DAO, found extracellularly and in the gut). and kidneys). 🇧🇷 Histamine can be metabolized in two ways: by oxidative deamination by DAO (old name: histaminase) or by intracellular ring methylation by histamine N-methyltransferase (HNMT). DAO is released into the circulation and concentrated in the small intestine, where it neutralizes dietary histamine or histamine produced by some intestinal bacteria from dietary histidine. HNMT breaks down histamine at the intracellular level. It is found in high concentrations in the liver, kidneys, lungs, eyes and lymph nodes and is important for the breakdown of histamine in the nervous system. HNMT is also important in the airways, where it protects against histamine in these tissues, including the bronchial epithelium, where it protects against histamine-induced asthma. Most people make too many of these enzymes to deal with the histamine influx, but when mast cells release too much histamine, there aren't enough enzymes to deal with it. In addition to running out of enzymes, they may not have enough nutrients to make the enzymes that break down histamine, or they may have a genetically reduced ability to make these enzymes.

There are histamine-rich foods, foods that compete for the same enzymes needed to break down histamine, and foods that trigger the release of histamine from mast cells. All of these categories will increase histamine levels and inflammation in the body of sensitive individuals. Histamine-rich foods include aged meat, spoiled meat, seafood, and fermented products. Also, histamine is made from the amino acid histidine. A carboxyl group is removed from the amino acid histidine and it is converted to histamine. Some bacteria and possibly yeast can convert histidine in food to histamine, so foods with fermented proteins can be high in histamine. Some intestinal bacteria can also convert histidine in food into histamine. Some intestinal flora increase the level of histamine in the intestine, while others reduce it. A product called Probiota Histaminx was made to specifically reduce histamine in the gut and is helpful for people with high histamine levels. When a person suffers from dysbiosis (imbalance of intestinal bacteria), they can produce histamine from any protein-rich food that contains histidine. These foods include beef, bison, pork, parmesan, pork, chicken, turkey, lamb, soybeans, fish such as tuna, catfish, and to a lesser extent seeds, nuts and beans, and even less grains.

There are also some foods that trigger the release of histamine from mast cells. These include citrus fruits, chocolate, seafood, tomatoes and pineapples. Also, some additives like MSG, sulfites, nitrites, benzoates and artificial colors can increase histamine responses in the body.

It's pretty sad when a person has a high or borderline histamine situation and they're using bone broth and fermented foods to support gut health, and all of a sudden they're a lot sicker than before. This is due to increased histamine levels.

That isThe link is the best list.of foods that contain or cause histamine release that I have found.

The drugs are known to block HNMT.

When a person takes any of these medications, it can increase excessive histamine levels in their body.

• Chloroquine (Amodiaquin, ein Malariamittel))

• Clorguanil

(Video) How Mast Cell Activation Syndrome, Mitochondrial Dysfunction, and the Brain Impact Your Patients

• Folate antagonists such as methoprin (HNMT requires folate for activity)

• Hydroxychloroquine

• Pirimetamina

• Promethazine

• Tacrine (anticholinesterase, drug for early Alzheimer's)

These drugs are known to block or inhibit the production of DAO

  • Alcohol
  • Nicotine
  • Acetylcysteine ​​(not a drug, a dietary supplement)
  • cimetidine
  • Dihydralase
  • clavulanic acid
  • metoclopramide
  • verapamil
  • Pimagedine (also known as aminoguanidine)
  • chloroquine
  • pentamidina
  • cycloserine
  • dobutamine
  • pancurônio
  • Radiological contrast media
  • morphine
  • metamizol
  • verapomilo
  • propenon
  • cefuroxima
  • calvulanic acid
  • cimetidine
  • tiopental
  • metoclopramide
  • amilorida
  • Ambroxl-aminofilina
  • Ibuprofen
  • Aspirin
  • Prozac
  • Zoloft
  • humira
  • Enbrel
  • Plaquenil
  • propanolol
  • metrapolol
  • Cardizem
  • Norvasc
  • alegre
  • Zyrtec
  • Benadryl
  • Tagamet
  • peptide
  • Zantac
  • some food additives

The drug diphenhydramine has been shown to increase DAO activity.

Additional support in enzyme production
  • Make sure the person has the nutrients for DAO, MAO and HNMT and is taking DAO with food.
  • DAO deficiency is related to low deficiencies of vitamin C, B6 and copper. Make sure they are appropriate as needed. Remember that long-term copper use should be taken with zinc in a 1:8 ratio (copper:zinc).
  • Bifidobacteria (useful probiotic that does not increase histamine; take after dinner and away from antimicrobials): A variety of bifidobacteria appear helpful, includingBifidobacterium infantis,long, short, two partsyof milkFurthermorelactobacillus plantsyPlatesthey are also useful.
  • HNMT is methylation dependent, so it is important to ensure there is adequate methylation support when needed. Two genetic variants that can affect methylation are MTHFR C677T rs1801133 and MTHFR A1298C rs1801131. There are also variants of the HNMT gene, but until more is known about them and ways to support the variants, there is no point in pursuing these.
Soothing herbs to consider if your gut is irritated by excess histamine
  • licorice
  • malvavisco
  • Wonderful
  • slippery elm
  • plane
Also consider good healing nutrients.
  • glutamine
  • zinc
  • vitamin A
  • Acetyl-L-Carnitine
  • Alpha Lipoic Acid: Chronic use may interfere with biotin and may require supplementation.
Helps with gas and bloating.
  • Red-haired
  • require

If the tests find pathogens, they must be treated first, or no amount of corrective activity will bring lasting relief.

Supports mast cell stabilization (immune support) and antihistamine activity
  • Fish oil to stabilize cell membranes and reduce inflammation/histamine leakage from mast cells
  • Vitamin C to stabilize mast cells, inhibit histamine and repolarize monocytes: small doses are often distributed throughout the day or 30 minutes before meals. If you can only take it twice a day: 500 mg twice a day.
  • Quercetin - high doses often help when low doses don't work - start with 250ml, may need 500mg 4 times a day or more if deemed necessary by the doctor. Slowly start increasing this dose over a few weeks. Some people may react and need very low doses.
  • Luteolin - mast cell stabilizer - 100-200 mg per day
  • (Neuroprotek LP - 40mg) Take 30 minutes before meals and one before bedtime.
  • One study found that mung bean sprouts (48 hours of sprout growth) provided significant protection against mast cell degranulation and histamine release due to its high flavonoid content. - 30 minutes before meals.
  • There are many herbs that stabilize mast cells and prevent histamine release.
  • Methylation support as deemed necessary by the clinician if methylation is not adequate, as HNMT does not function well when methylation is reduced (most of its methylation activity goes into the production of phosphatidylcholine and creatine, so supplementation may help address the need to reduce methylation if this is an issue for the individual)
    Methylation support is important If there is impaired methylation due to the MTHFR single nucleotide polymorphism, consider methylation support with B12, folate, B6 (as pyridoxal-5-phosphate), trimethylglycine, and riboflavin.
  • Perimine (perilla seed extract): one capsule 30 minutes before meals.
  • AllQlear - Made from quail eggs. Contains a tryptase blocker: Tyrptase is another mediator released by mast cells. 1-2 tablets 30 minutes before meals.
  • Regaliz - not for high blood pressure or edema
  • Turmeric – Long Turmeric
  • Glutathione - Antioxidant that helps neutralize inflammatory mediators. If there isn't enough of it, inflammation will increase as oxidative stress causes the mast cells to release more chemicals and there will be more histamine. There is an additional need to neutralize inflammatory mediators produced by mast cells and an increased need for glutathione. You can see an inflammatory circle forming here. Glutathione and other sulfur-containing foods and supplements can feed bacteria in the gut that produce hydrogen sulfide and cause intestinal inflammation, which can sometimes affect the lining of the intestine. If this happens, you likely have an overgrowth of these bacteria and want to reduce it. You may also need to cut back on sulfur supplements a bit.
  • Resveratrol
  • Some Bifidobacterium spp. have been shown to be helpful, as many lactobacilli produce histamine. However, I've seen conflicting research and right now I feel like there's a lot of confusion about this. However, I used a product called Probiota Histaminx, which contains bacteria that don't seem to produce histamine and are used to flush out histamine makers.

There are many herbs that stabilize mast cells and prevent histamine release.

Stabilization of polyphenols and mast cells

Foods rich in a class of polyphenols called flavonoids can help decrease mast cell activation and reduce histamine in the body. These flavonoids include quercetin and catechin, found in herbs such as green tea, chamomile, hawthorn and ginkgo. Quercetin is found in many foods/herbs and some good choices for quercetin levels include garlic, onions, capers, red or dark blue fruits like cranberries and blueberries. Elderberries are rich in quercetin, as are blackberries and kale. Quercetin's anti-inflammatory activity appears to derive from its antioxidant effects and inhibition of cyclooxygenase and lipoxygenase, which in turn regulate the inflammatory mediators leukotrienes and prostaglandins. Quercetin has been shown to stabilize mast cells, thereby inhibiting histamine release. The USDA has compiled a large list ofFoods rich in quercetin at this link.

Research studies have identified herbal compounds that stabilize mast cells
  • Epigallocatechin gallate found in green cha.Kamelie sinensisMay inhibit histamine release from mast cells.
  • Theanine is another component of green tea -Kamelie sinensis🇧🇷 This amino acid has been shown to prevent the release of histamine from cells at low levels.
  • Ellagic acid, found in fruits such as raspberries, strawberries, walnuts and pomegranates, inhibits the release of histamine and pro-inflammatory cytokines such as TNF-alpha and Il-6.
  • Khellin de la hierba Khella –Ammi VisnagaIt has been shown to stabilize mast cells. This is also an herb used to prevent asthma attacks. I have found it particularly helpful for exercise-induced asthma in the past. Khella is not an herb used for instant relief and high doses can cause side effects such as liver damage).
  • Silibinin from the Herb Milk Thistlemarian whistleprevents the release of histamine and other inflammatory cytokines from mast cells.
  • Reservatrol in Japanese Knuckle Grass -polygon vertex, as well as the foods grapes, peanuts and cranberries, have been found to suppress inflammatory cytokines associated with mast cell disorders, particularly tumor necrosis factor and interleukins.
  • Turmeric Herb Curcumin –turmeric is longprevents histamine release by stabilizing mast cells and inhibits IL-4 and TNF-alpha cytokines.
  • Parthenolides from the herb Matricaria –Parthenium tanacetastabilize mast cells.
  • Indoling the Kraut Wide - Ienough dyesstabilized mast cells.
  • basil tarragon -there is basiliskreduces inflammation caused by edema and arachidonic acid.
Additional foods/herbs that may be helpful in stabilizing mast cells or decreasing histamine release
  • timio
  • Brunnenkresse
  • pea sprout
  • onion
  • this
  • black cumin
  • require
  • Chamomile
  • Tarragon
  • Nessel
  • Red-haired
  • Turmeric
  • apples
  • granada
  • peaches
  • In peace


Peptides can also be helpful. BPC-157, TB4 frag and KPV can be useful for a doctor. The TB4 fragment is different from TB4. TB4 stimulates mast cell activation, while the TB4 fragment does not.

In mastitis

I cannot end this article without mentioning mastocytosis. This differs from mast cell activation or high histamine levels for other reasons.

(Video) Mast Cell Activation Syndrome – The Better Approach To Healing Chronic Illnesses | Dr. Eric Gordon

Mastocytosis has to do with the proliferation of mast cells. There is inappropriate mast cell activation, where the mast cells release their contents more easily than normal. In addition, there are an excessive number of mast cells manufactured by the body. There are two main types.

  • Cutaneous: restricted to the skin only
  • Systemic - distributed throughout the body

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Can you heal from mast cell activation syndrome? ›

There is no cure for the condition. You will need to avoid triggers and use medications. If you have anaphylactic reactions, your doctor might also give you an auto-injector epinephrine pen to use in emergencies.

How do you calm down a MCAS flare? ›

Treatments can include:
  1. H1 or H2 antihistamines. These block the effects of histamine, which is one of the primary mediators that mast cells release. ...
  2. Aspirin. This may decrease flushing.
  3. Mast cell stabilizers. ...
  4. Antileukotrienes. ...
  5. Corticosteroids.

What is the life expectancy of someone with mast cell activation syndrome? ›

People with SM and MCAS are frequently reassured that they will live a normal life span. People with SM-AHNMD are quoted an average survival of about 8.5 years; ASM, 3.5 years; MCL, under a year.

What is the root cause of mast cell activation syndrome? ›

There may be underlying causes of mast cell activation syndrome for many people, including toxins, mold exposure, infections, and other environmental exposures. It is important to identify the potential causes with proper testing to improve symptoms and improve the outcome of treating mast cell activation syndrome.

Does vitamin C stabilize mast cells? ›

Vitamin C is important in mast cell activation disorder for its role in the breakdown of histamine and as a mast cell stabilizer. Vitamin C is also a co-factor in collagen synthesis, making it a potentially important nutrient in Ehlers-Danlos syndrome and other connective tissue disorders.

What vitamins stabilize mast cells? ›

Vitamins have been shown to have a protective effect on the body's immune cells. Vitamin C and E are necessary in allergic disease treatment where mast cells are involved. In addition, ascorbic acid and pyridoxine are useful compounds for the treatment of inflammatory disorder of the respiratory airways.

Does vitamin D help with MCAS? ›

For people with mast cell activation syndrome (MCAS), the stabilizing influence of vitamin D is essential. While it is difficult in many cases to determine the exact cause of MCAS, vitamin D deficiency may play a role.

What foods stabilize mast cells? ›

I recommend including foods that may help to stabilize your mast cells into your diet, including:
  • Watercress (7)
  • Moringa (8)
  • Chamomile (9)
  • Turmeric (10)
  • Thai ginger or galangal (11)
  • Apples (12)
  • Brazil nuts (13)
  • Peaches (14)
30 Dec 2021

Does magnesium help MCAS? ›

Like Vitamin C, magnesium is a co-factor in the production of diamine oxidase. Magnesium deficiency has been seen to increase mast cell production in some cases; therefore magnesium supplementation may be helpful in controlling mast cell division.

What does a mast cell flare feel like? ›

Dry eyes, red itchy and red burning, runny nose, and inflammation ulcers of the mouth may be seen in the head and neck organ system. In regard to the chest and heart, chest discomfort, rapid heartbeats, redness, flushing of the skin, sudden dizziness, hot flashes, and blood pressure surges may be seen.

Does Benadryl help mast cell activation syndrome? ›

Diphenhydramine (DPH) is a well tolerated histamine H1 receptor blocker which can quickly suppress MC activation and is used to treat allergic reactions and anaphylaxis.

How serious is mast cell activation syndrome? ›

Mast cells build up in the skin, causing red or brown lesions that itch. By itself, cutaneous mastocytosis isn't life-threatening. But people with the disorder have significant symptoms and have a much higher risk of a severe allergic reaction, which can be fatal.

How rare is mast cell activation syndrome? ›

On the common end of the spectrum, atopic disorders, such as allergic rhinitis and allergic asthma, can affect up to 10% to 30% of the general population. 1 In contrast, mastocytosis and monoclonal mast cell activation syndrome (MMAS) might be as rare as 1 in 10,000 to 20,000 subjects.

Does mast cell activation syndrome shorten your life? ›

Survival of patients with advanced SM is significantly shorter than that of the general population and is affected by disease subtype.

Can anxiety trigger mast cell activation? ›

Abstract. Mental or emotional stress has been shown to cause mast cell degranulation in several different tissues.

Can COVID trigger mast cell activation syndrome? ›

Both mast cell activation syndrome and long COVID cause multiple symptoms. It is theorised that COVID-19 infection could lead to exaggeration of existing undiagnosed mast cell activation syndrome, or could activate normal mast cells owing to the persistence of viral particles.

Is mast cell an autoimmune disease? ›

Mast cells are important in innate immune system. They have been appreciated as potent contributors to allergic reaction. However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis.

Does B12 stabilize mast cells? ›

Vitamin B12 significantly inhibits mast cell degranulation by 27% at 0.00015%.

Does ginger stabilize mast cells? ›

Because of its anti-inflammatory properties, it may work against allergies as well. "A 2016 animal study showed ginger suppressed production of certain cytokines that cause mast cell activation, thereby leading to prevention and alleviation of allergic rhinitis symptoms," she says.

Do probiotics help with mast cell? ›

CONCLUSION: Certain probiotic bacteria might diminish mast cell allergy-related activation by downregulation of the expression of high-affinity IgE and histamine receptor genes, and by inducing a pro-inflammatory response.

What is the strongest mast cell stabilizer? ›

Within the flavone class, the most active mast cell stabilizers are luteolin, disometin and apigenin.

Does zinc stabilize mast cells? ›

Few molecules are known to possess both mast cell stabilizing and gastrointestinal cytoprotective activity. These include zinc compounds, sodium cromoglycate, FPL 52694, ketotifen, aloe vera, certain flavonoids such as quercetin, some sulfated proteoglycans such as chondroitin sulfate and dehydroleucodine.

Is turmeric a mast cell stabilizer? ›

Curcumin, the active ingredient of the curry spice turmeric, has anti-inflammatory properties, and thus may have the capacity to regulate Th2 cells and mucosal mast cell function during allergic responses.

What drugs block mast cells? ›

The mast cell stabilizers cromolyn and nedocromil work by blocking a calcium channel that is essential for mast cell degranulation (the release of chemical mediator-containing secretory granules which occurs after exposure to a specific antigen).

Is magnesium high in histamine? ›

Other than magnesium citrate and additives, most forms of magnesium should be low histamine as well as mast cell and histamine supportive.

Is honey a mast cell stabilizer? ›

As described above, although limited, the preclinical studies mainly demonstrate that honey can significantly inhibit mast cell degranulation, anti-allergen IgE levels, as well as improve all the histopathological parameters of allergic asthma (Table 3).

What foods should I avoid with mast cell activation? ›

There are foods that patients with mast cell disease seems to be more reactive to overall. These include but are not limited to: Monosodium Glutamate (MSG), alcohol, shellfish, artificial food dyes and flavorings, food preservatives, pineapples, tomatoes & tomato based products, and chocolate.

What should I avoid with mast cell disease? ›

In general, people with mast cell diseases react more frequently to monosodium glutamate (MSG), shellfish, alcohol, food preservatives, artificial food dyes and flavoring additives, pineapples, any products made from tomatoes, and chocolate.

What vitamins break down histamine? ›

There is also interest around vitamin co-factors which aid the DAO enzyme in degrading histamine, such as the B complex vitamins. Vitamin B6 and Vitamin C, in particular, have been shown to reduce symptoms of seasickness and histamine intolerance.

Does zinc lower histamine? ›

The zinc chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) inhibits the release of histamine, the production of cytokines, and the secretion of lipid mediators in mast cells, and zinc supplementation rescues these inhibitory effects.

What organ produces histamine? ›

Histamine is a neurotransmitter that is released from histaminergic neurons which project out of the mammalian hypothalamus. The cell bodies of these neurons are located in a portion of the posterior hypothalamus known as the tuberomammillary nucleus (TMN).

Is there a blood test for mast cell activation syndrome? ›

The patient's blood should be tested for mutation of mast cell growth receptor KIT, called KIT D816V. If positive, it indicates a clonal mast cell disorder.

Can stress trigger mast cells? ›

Stress conditions activate mast cells to release prestored and newly synthesized inflammatory mediators and induce increased blood-brain barrier permeability, recruitment of immune and inflammatory cells into the brain and neuroinflammation.

Can leaky gut cause mast cell activation? ›

Leaky gut syndrome, SIBO, dysbiosis, and candida have all been shown to influence mast cell activation and increase histamine production. Gastrointestinal symptoms are one of the most frequent symptoms of MCAS.

What is the best antihistamine for mast cell? ›

Drugs that modulate the symptoms of mast cell activation

Non-sedating H1 antihistamines, eg cetirizine, loratadine, fexofenadine, are often preferred. H2 receptor antagonists, eg ranitidine, may be particularly useful for gastrointestinal symptoms of heartburn and epigastric pain.

What tea can I drink with MCAS? ›

Ginger tea

Anecdotally, I've found that many people with MCAS or histamine intolerance find ginger to be helpful, given that it is anti-inflammatory.

How much quercetin should I take for mast cell activation syndrome? ›

For patients with mast cell activation syndrome (MCAS), taking up to 500mg of quercetin 30 to 40 minutes before eating can substantially reduce histamine release during meals.

Does mast cell disorder go away? ›

There is no cure for mastocytosis, but treatments can help minimize symptoms. To manage it, you'll need to avoid triggers that might cause an attack.

Does mast cell disease go away? ›

In children the symptoms of cutaneous mastocytosis usually improve over time, but remain stable in adults. In many cases the condition gets better on its own by the time a child has reached puberty. The outlook for systemic mastocytosis can vary, depending on the type you have.

Is mast cell activation syndrome progressive? ›

Patients typically suffer from rapidly progressive organopathy involving the liver, bone marrow and other organs. The bone marrow typically shows a diffuse, dense infiltration with mast cells.

Is mast cell activation syndrome debilitating? ›

The second type of MCAD is mast cell activation syndrome (MCAS). MCAS can cause a wide range of unpleasant and sometimes debilitating, symptoms in any of the different systems of the body, frequently affecting several systems at the same time.

Can mast cells affect the brain? ›

Mast cells both promote deleterious outcomes in brain function and contribute to normative behavioral functioning, particularly cognition and emotion. Mast cells may play a key role in treating systemic inflammation or blockade of signaling pathways from the periphery to the brain.

What kind of doctor treats mast cell activation syndrome? ›

If you suspect you may have a mast cell disease, a board-certified allergist or immunologist is a good place to start. Other specialists include gastroenterologists, dermatologists, hematologists and endocrinologists.

Is MCAS a neurological disorder? ›

MCAS patients often experience increased activation of sensory and motor nerves. This manifests as generic neurologic symptoms, sometimes several at once, like tingling, numbness, paresthesia and tics.

Can mold cause mast cell activation? ›

Exposure to hidden mold in your home or office can lead to a number of health problems, some of them quite serious. One such problem which often goes undiagnosed and is highly under-recognized is Mast cell activation syndrome.

Can MCAS affect your heart? ›

It can cause acute heart failure, ventricular arrhythmias, and acute heart failure.

Is MCAS an immune deficiency? ›

Mast Cell Activation Disorder As A Presentation Of Primary Immunodeficiencies.


1. Mast Cell Activation Syndrome: The Functional Medicine Approach
(The Institute for Functional Medicine)
2. BBC Look East - Nicola Haseler report on Long Covid and Mast Cell Activation Syndrome
(nicola haseler)
3. 3 Months of Healing my Gut - learning to live with Mast Cell Activation Syndrome
(More Than Just An Allergy)
4. The Root Causes of Mast Cell Activation Syndrome (MCAS) and How to Restore Order to the Mast Cells
(Restorative Chiropractic & Functional Wellness Center)
5. Anne Maitland - Living with Mast Cell Activation Syndrome
(The Ehlers-Danlos Society)
6. Peter Vadas, MD, Immunology | Advances In Our Understanding Of Mast Cell Activation Syndrome
(The ILC Ehlers Danlos & Chronic Pain Foundation)


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