Metoprolol Succinate ER 25 mg 24-hour extended-release tablet (2023)

7168drug name

generic name:
Metoprololsuccinat Retardtablette – oral

(MET-oh-PROE-lol SUX-i-nate)

Toprol XL


Do not stop taking this medicine without talking to your doctor. Some conditions may get worse if you suddenly stop taking this medication. Some people who suddenly stop taking similar medications have experienced chest pain, heart attacks, and irregular heartbeats. If your doctor decides that you should stop using this medicine, your doctor may instruct you to gradually reduce your dose over 1 to 2 weeks.

If you are gradually withdrawing this medicine, it is recommended that you temporarily limit physical activity to relieve the strain on your heart. Seek medical help immediately if you experience chest pain/tightness/pressure, chest pain that spreads to your jaw/neck/arm, unusual sweating, difficulty breathing, or fast/irregular heartbeat.


This medication is a beta-blocker used to treat chest pain (angina pectoris), heart failure and high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.

This medication blocks the effects of certain natural chemicals in your body (such as adrenaline) that affect your heart and blood vessels. This reduces heart rate, blood pressure and pressure on the heart.

Other uses

This section contains uses of this medication not listed on the US approved professional label. for the medicine, which however can be prescribed by your doctor. For any condition listed in this section, use this medication only if prescribed by your doctor.

This medication can also be used to improve survival if you have an abnormal heart rhythm or after an acute heart attack. It can also be used to reduce the risk of migraines.

type of use

See also the Notice section.

Take this medication by mouth, usually once daily, as directed by your doctor. This medicine can be taken with or without food.

Do not crush or chew extended-release tablets. This allows all of the drug to be released at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they are labeled and your doctor or pharmacist advises you to do so. Swallow the tablet whole or divided without crushing or chewing.

To reduce the risk of side effects, your doctor may ask you to start taking this medicine at a low dose and gradually increase the dose. Carefully follow your doctor's instructions. Dosage depends on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not suddenly stop taking this medication without consulting your doctor. Your condition may get worse if the medicine is suddenly stopped.

When used to treat high blood pressure, it may take several weeks for this medication to take full effect. Continue to take this medicine even if you feel well. Most people with high blood pressure do not feel bad.

To prevent chest pain, a second heart attack or migraines, it is very important to take this medication regularly as directed. This medication should not be used to treat chest pain or migraines, if they occur. Use other medications to relieve sudden attacks (eg sublingual nitroglycerin tablets for chest pain, "triptan" medications such as sumatriptan for migraines) as directed by your doctor. For more information, contact your doctor or pharmacist.

Tell your doctor if your condition does not improve or gets worse (for example, if your usual blood pressure levels remain high or increase, if chest pains or migraines occur more frequently).

Side effects

See also the Notice section.

Drowsiness, dizziness, fatigue, diarrhea, and slow heartbeat may occur. Reduced sexual performance has rarely been reported. If any of these side effects persist or get worse, tell your doctor or pharmacist right away.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

With some brands of this medication, an empty pill capsule can form in the stool. This is harmless.

This medicine can reduce blood flow to your hands and feet and make you feel cold. Smoking can enhance this effect. Dress warmly and avoid tobacco.

Remember, this medication has been prescribed for you because your doctor has decided that the benefit to you is greater than the risk of side effects. Many people who take this medication do not experience serious side effects.

Tell your doctor right away if you experience any serious side effects, such as:

  • very slow heartbeat
  • severe dizziness
  • to faint
  • blue toes/feet
  • New or worsening symptoms of heart failure (such as shortness of breath, swollen ankles/feet, unusual tiredness, unusual/sudden weight gain)
  • Mental/mood changes (such as confusion, mood swings, depression)

A very serious allergic reaction to this drug is rare. However, seek medical attention right away if you experience symptoms of a severe allergic reaction, such as:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness

This is not a complete list of possible side effects. If you notice any other side effects not listed above, talk to your doctor or pharmacist.

US United States -

Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088 or at

In Canada: Call your doctor for medical advice about side effects. You can report side effects to Health Canada at 1-866-234-2345.


Before taking metoprolol, tell your doctor or pharmacist if you are allergic to it. or to other beta-blockers (such as atenolol, propranolol). or if you have other allergies. This product may contain inactive ingredients that may cause allergic reactions or other problems. For more details, talk to your pharmacist.

Before using this medication, tell your doctor or pharmacist about your medical history, especially about:

  • certain types of cardiac arrhythmias (eg, slow heart rate, second- or third-degree atrioventricular block, mild sinus syndrome)
  • Breathing problems (such as asthma, chronic bronchitis, emphysema)
  • liver disease
  • severe allergic reactions, including those that require adrenaline treatment
  • Circulatory disorders (eg, Raynaud's disease, peripheral vascular disease)
  • Mental/mood disorders (eg, depression)
  • a certain muscle disease (myasthenia gravis)

This medicine may make you dizzy or drowsy. Alcohol or marijuana (cannabis) may increase dizziness or drowsiness. Do not drive, use machinery or do anything that requires your attention until it is safe to do so. Limit or avoid alcoholic beverages. Talk to your doctor if you use marijuana (cannabis).

Before surgery, tell your doctor or dentist about all products you use (including prescription drugs, over-the-counter drugs, and herbal products).

This product can prevent the rapid heartbeat you usually feel when your blood sugar levels drop too low (hypoglycemia). The risk is greater if you have diabetes, vomit, fast, or don't eat regularly. Other symptoms of low blood sugar, such as dizziness and sweating, are not affected by this medication.

If you have diabetes, this product may make it difficult for you to control your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor right away if you experience symptoms of high blood sugar, such as B. Increased thirst/urination. Your doctor may need to adjust your diabetes medications, exercise program, or diet.

Children may be at greater risk of low blood sugar (hypoglycemia) while taking this medication, particularly if they vomit or do not eat regularly. To avoid low blood sugar, make sure children eat regularly. If your child is not eating regularly, is vomiting, or has symptoms of low blood sugar (eg, sweating, shaking), tell the doctor right away.

During pregnancy, this medication should not be used unless clearly necessary. It may harm the unborn baby. Discuss the risks and benefits with your doctor.

This medication passes into breast milk, but it is unlikely to harm a breastfed baby. Consult your doctor before breastfeeding.

Interactions with other drugs

Drug interactions can change the way the drug works or increase your risk of serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share them with your doctor and pharmacist. Do not take, stop or change the dosage of any medication without your doctor's approval.

A product that may interact with this medication is:

  • Fingolimod

Other medicines can affect how metoprolol is removed from your body, which can affect how metoprolol works. Examples include lumefantrine, propafenone, quinidine, SSRI antidepressants (such as fluoxetine, paroxetine) and St. John's wort, among others.

Some products contain ingredients that can increase your heart rate or blood pressure or make your heart failure worse. Tell your pharmacist what products you use and ask how to use them safely (especially cough and cold remedies, dietary supplements or NSAIDs like ibuprofen/naproxen).


If someone has overdosed and has severe symptoms, such as fainting or difficulty breathing, call 911. If not, call a poison control center right away. US citizens can call their local Poison Control Center at 1-800-222-1222. Canadian residents can call a provincial poison control center. Symptoms of overdose may include: very slow heartbeat, severe dizziness, severe weakness, fainting, difficulty breathing.


Do not share this medicine with others.

Talk with your doctor about lifestyle changes that may help this medication work better (such as stress reduction programs, exercise, and dietary changes).

Check your blood pressure and pulse (heart rate) regularly while you are taking this medication. Learn how to measure your blood pressure and heart rate at home and share the results with your doctor.

Laboratory tests and/or medical tests (eg, liver function tests) should be performed while taking this medication. For more details, consult your doctor.

missed dose

If you forget a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Take the next dose at the regular time. Do not double the dose to make up the difference.

save not computer

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications out of the reach of children and pets.

Do not flush medicine down the toilet or drain unless instructed to do so. Dispose of this product properly when it expires or is no longer needed. Contact your pharmacist or local waste disposal service.

medical alert

Your condition could complicate a medical emergency. For information on registering with MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

important note

HOW TO USE THIS INFORMATION: This is a summary and does NOT contain all possible information about this product. This information does not guarantee that this product is safe, effective or suitable for you. This information does not constitute individual medical advice and does not replace the advice of your physician. Always consult your physician for complete information about this product and your specific health needs.

Information last revised in April 2023.

Copyright(c) 2023 First Databank, Inc.


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